Bioprocessing Development
Our company offers end-to-end bioprocessing development services, optimizing both upstream process development and downstream process development.
At CuriRx, our cell culture and purification facility produces biologics that alleviate product development bottlenecks or capacity shortfalls.
Cell Line and Strain Development
âś” GS and DHFR expression systems
âś” CHO (ExpiCHO, CHOK1, CHOZNek)
✔ EColi, Yeast, saccharomyces cerevisiae, Pichia pastoris
âś” High throughput screening for high biomass/titer producer
âś” Single cell isolation (FACS)
âś” Clonality assessment (Cell imager)
âś” Analytical confirmation
Upstream Process Development
✔ Media & feed screening, development, and optimization
âś” Fed-batch/ continuous bioreactor conditions development
✔ Recovery and separation development
✔ Cell disruption and protein refolding
✔ Process scale up and down
✔ Upstream process characterization
Downstream Process Development
âś” Resin screening
âś” Chromatography development and optimization
âś” Filtration (TFF and depth filters) development and sizing
âś” Bulk formulation development
âś” Viral clearance and inactivation steps development
âś” Downstream process Characterization