Bioprocessing Development
We offer end-to-end bioprocessing development services, optimizing both upstream and downstream processes.
At CuriRx, our cell culture and purification facility produces biologics that alleviate product development bottlenecks or capacity shortfalls.
![Cell Culture](https://curirx.com/wp-content/uploads/2017/05/CellCulture.jpg)
Cell Line and Strain Development
✔ GS and DHFR expression systems
✔ ExpiCHO
✔ High throughput screening for high biomass/titer producer
✔ Single cell isolation (FACS)
✔ Clonality assessment (Cell imager)
✔ Analytical confirmation
Upstream Process Development
✔ Media & feed screening, development, and optimization
✔ Fed-batch/ continuous bioreactor conditions development
✔ Recovery and separation development
✔ Cell disruption and protein refolding
✔ Process scale up and down
✔ Upstream process characterization
Downstream Process Development
✔ Resin screening
✔ Chromatography development and optimization
✔ Filtration (TFF and depth filters) development and sizing
✔ Bulk formulation development
✔ Viral clearance and inactivation steps development
✔ Downstream process Characterization