Small Molecule Pharmaceuticals

Small, chemically manufactured molecules are the classic active drug substances that continue to make up most pharmaceuticals on the market today. CuriRx provides a comprehensive range of contract analytical services to the pharmaceutical industry for raw materials, intermediates, active pharmaceutical ingredients (APIs) and drug products.

For these pharmaceuticals, the services we offer include, but are not limited to:

• General compendial testing
• ICH stability storage and testing
• Method development, qualification, and validation
• Elemental composition and impurities
• Impurities and drug content using different modes of HPLC
• Identification and quantification of impurities by GC or GC-MS, head space GC, HR-LC-MS
• Spectroscopic and spectrometric characterization (MS, FTIR, UV)
• Particle size analysis
• Microscopy
• Solubility (aqueous and non-aqueous)
• pKa
• Partition coefficient
• Solid-state properties (DSC)
• Compatibility with typical excipients and packaging material
• Moisture content by Karl-Fisher
• Dissolution studies in gastric or intestinal fluids